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Synthesis and Fungicidal Activity of ( E )‐α‐(Methoxyimino)benzeneacetate Derivatives Containing 1,2,4‐Triazole Schiff Base Side Chain
Author(s) -
Song HongXing,
Shi DeQing
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1795
Subject(s) - chemistry , alternaria solani , schiff base , triazole , fungicide , side chain , stereochemistry , alternaria , rhizoctonia solani , organic chemistry , botany , biology , polymer
To find new strobilurin analogs with high activity against resistant pathogens, twelve ( E )‐α‐(methoxyimino)benzeneacetate derivatives containing 1,2,4‐triazole Schiff base side chain 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j , 3k , 3l were designed and synthesized. Their structures were confirmed by IR, 1 H‐NMR, EIMS, and elemental analyses. Bioassays indicated that most of the target compounds showed moderate to good fungicidal activities against Physalospora piricola Nose and Alternaria solani . For example, compounds 3d , 3e , and 3f possessed 99.5%, 100%, and 95.6% inhibition against Physalospora piricola Nose , whereas compounds 3d , 3f , and 3g exhibited 92%, 91%, and 92% inhibition against Alternaria solani at the concentration of 50 mg/L, respectively.