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A Facile One‐Pot Synthesis of Chloropyridines from Chalcones
Author(s) -
Me Prasanth K.,
Krishnaraj K. U.,
George Sholly C.,
Devaky K. S.,
Anabha E. R.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1790
Subject(s) - chemistry , malononitrile , aromatization , adduct , intramolecular force , michael reaction , aryl , medicinal chemistry , organic chemistry , catalysis , alkyl
Malononitrile undergoes Michael addition to iminoalkylated chalcones under Vilsmeier–Haack reaction condition. In situ intramolecular cyclization followed by aromatization of the adduct resulted in the formation of 4,6‐bis(aryl)‐2‐chloropyridines in good yields.