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Synthesis and potent antifungal activity against Candida species of some novel 1 H ‐benzimidazoles
Author(s) -
Göker Hakan,
Alp Mehmet,
AteşAlagöz Zeynep,
Yıldız Sulhiye
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.179
Subject(s) - chemistry , antifungal , indole test , pyridine , benzimidazole , stereochemistry , in vitro , aryl , minimum inhibitory concentration , organic chemistry , microbiology and biotechnology , biochemistry , alkyl , biology
AbstractA series of 47 novel N 1 ‐alkylated‐2‐aryl‐5(6)‐substituted‐1 H ‐benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80 , having pyridine at the position C‐2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25–3.12 μg/mL. Indole analogues 108‐110 have no inhibitory activity. J. Heterocyclic Chem., (2009).