Synthesis and potent antifungal activity against  Candida  species of some novel 1 H ‐benzimidazoles | Zendy

Göker Hakan | Zendy; Alp Mehmet | Zendy; AteşAlagöz Zeynep | Zendy; Yıldız Sulhiye | Zendy

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Synthesis and potent antifungal activity against Candida species of some novel 1 H ‐benzimidazoles

Author(s) -

Göker Hakan,

Alp Mehmet,

AteşAlagöz Zeynep,

Yıldız Sulhiye

Publication year - 2009

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.179

Subject(s) - chemistry , antifungal , indole test , pyridine , benzimidazole , stereochemistry , in vitro , aryl , minimum inhibitory concentration , organic chemistry , microbiology and biotechnology , biochemistry , alkyl , biology

A series of 47 novel N 1 ‐alkylated‐2‐aryl‐5(6)‐substituted‐1 H ‐benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80 , having pyridine at the position C‐2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25–3.12 μg/mL. Indole analogues 108‐110 have no inhibitory activity. J. Heterocyclic Chem., (2009).

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