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Synthesis of some novel 3‐alkyl/aryl‐6‐((1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)methyl)‐[1,2,4]triazolo[3,4‐ b ][1,3,4]thiadiazoles
Author(s) -
Chen Xiqing,
Liu Chenjiang,
Wang Jide,
Li Yanping
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.178
Subject(s) - chemistry , thiadiazoles , aryl , alkyl , benzotriazole , acetic acid , condensation reaction , stereochemistry , proton nmr , medicinal chemistry , organic chemistry , catalysis
A series of 3‐alkyl/aryl substituted‐6‐((1 H ‐benzo[ d ][1,2,3]triazol‐1‐yl)methyl)‐[1,2,4]triazolo[3,4‐ b ][1, 3,4]thiadizoles 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l , 4m are prepared by the condensation of 3‐alkyl/aryl substituted‐4‐amino‐5‐mercapto‐1,2,4‐triazoles 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , 2i , 2j , 2k , 2l , 2m with benzotriazole‐1‐yl acetic acid 3 through a single step reaction. The structures of all newly synthesized compounds are established on the basis of their IR, 1 H NMR, and elemental analyses data. Two selected compounds 4l and 4m are investigated for their analgesic and anti‐inflammatory activities; they showed weak anti‐inflammatory activity and no analgesic activity. J. Heterocyclic Chem., (2010).