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Synthesis and Biological Evaluation of Novel Benzoxaboroles as Potential Antimicrobial and Anticancer Agents
Author(s) -
Sravan Kumar J.,
Alam M. A.,
Gurrapu Shirisha,
Nelson Grady,
Williams Michael,
Corsello Michael A.,
Johnson Joseph L.,
Jonnalagadda Subash C.,
Mereddy Venkatram R.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1777
Subject(s) - chemistry , antimicrobial , antifungal , aldol reaction , combinatorial chemistry , organic chemistry , microbiology and biotechnology , catalysis , biology
Several novel benzoxaborole derivatives were synthesized starting from 2‐formylphenylboronic acid utilizing Baylis–Hillman reaction , Barbier allylation , Passerini reaction , and aldol reaction protocols as the key step. All the synthesized benzoxaboroles have been evaluated for their antibacterial, antifungal, and anticancer activities.