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Three‐Component Uncatalyzed Eco‐Friendly Reactions for One‐Pot Synthesis of 4,7‐Dihydro[1,2,4]triazolo[1,5‐ a ]pyrimidine Derivatives
Author(s) -
El Rady Eman A.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1771
Subject(s) - chemistry , environmentally friendly , pyrimidine , yield (engineering) , catalysis , combinatorial chemistry , condensation , organic chemistry , component (thermodynamics) , ethanol , condensation reaction , one pot synthesis , multi component reaction , stereochemistry , ecology , materials science , physics , metallurgy , biology , thermodynamics
A three‐component system of one‐pot synthesis of [1,2,4]triazolo[1,5‐ a ]pyrimidine derivatives using condensation of 1,3‐dicarbonyl compounds, aldehydes, and 5‐amino[1,2,4]triazole in ethanol without any catalyst was reported in high yields via simple, efficient, and environmentally friendly process. The method reported herein considered a green process; this method has significant advantages of simple workup procedure, excellent yield, minimal environmental pollution, and short reaction time over classical reported methods.