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Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]‐oxadiazoles with fluorobenzimidazoles
Author(s) -
Jadhav Ganesh R.,
Shaikh Mohammad U.,
Kale Rajesh P.,
Ghawalkar Anand R.,
Gill Charansingh H.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.177
Subject(s) - chemistry , imidazole , antimicrobial , staphylococcus aureus , amine gas treating , antibacterial activity , escherichia coli , chloride , pseudomonas aeruginosa , in vitro , condensation , organic chemistry , nuclear chemistry , bacteria , biochemistry , gene , biology , physics , thermodynamics , genetics
In this study, a novel series of substituted 4,6‐difluoro‐2‐{2‐[3‐(substituted‐phenyl)‐[1,2,4]‐oxadiazol‐5‐yl]‐ethyl}‐1 H ‐benzo[d]imidazole derivatives were synthesized by condensation of 2,4‐difluoro 6‐nitrophenyl amine with 3‐(substitutedphenyl‐[1,2,4]‐oxadiazol‐5yl) propionic acid by using 2,4,6‐trichlorobenzoyl chloride in the presence of triethyl amine base. The compounds were evaluated for their preliminary in vitro antibacterial activity against Pseudomonas aeruginosa , Escherichia coli , Staphylococcus aureus , and Salmonella typhosa . The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed moderate activity with reference standard Gentamycin. J. Heterocyclic Chem., (2009).