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A Green Synthesis of Pyrrolo[1,2‐ a ]quinazolin‐5(1 H )‐one Derivatives in Ionic Liquids Catalyzed by Iodine
Author(s) -
Zhou JieXing,
Lu Lian,
Li TuanJie,
Yao ChangSheng,
Wang XiangShan
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1768
Subject(s) - chemistry , ionic liquid , catalysis , iodine , benignity , medicinal chemistry , reaction conditions , ionic bonding , tetrafluoroborate , organic chemistry , combinatorial chemistry , ion , biology , malignancy , genetics
A series of 2,3,3 a ,4‐tetrahydro‐3 a ‐methylpyrrolo[1,2‐ a ]quinazolin‐5(1 H )‐one derivatives were synthesized by a reaction of 2‐aminobenzamide and 5‐chloropentan‐2‐one at 80 °C catalyzed by iodine in ionic liquid of [BMIm]Br. Compared with the other methods, this novel method has the advantages of milder reaction conditions, high yields, environmental benignity, and metal‐free catalyst.