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Ethyl {4‐[2‐(saccharin‐2‐yl)acetylsulfamoyl]phenylazo}cyanoacetate in the synthesis of polyfunctionally heteroaromatic derivatives
Author(s) -
Aly A. A.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.176
Subject(s) - chemistry , methylene , ethyl cyanoacetate , reagent , antimicrobial , pyrimidine , derivative (finance) , organic chemistry , saccharin , nucleophile , malononitrile , combinatorial chemistry , stereochemistry , medicine , financial economics , economics , endocrinology , catalysis
An efficient and direct one‐pot reaction of ethyl saccharinylcyanoacetate derivative 3 with a variety of active methylene reagents and nitrogen nucleophiles afforded novel series of polyfunctionally substituted heteroaromatic derivatives 5–13 , respectively. The pyrazole derivative 13 was seemed to be the excellent precursors for the synthesis of pyrazolo[1,5‐a]pyrimidine derivatives 14–24 . The antimicrobial screening of some synthesized products was evaluated against some selected bacteria and fungi. The structures of the synthesized derivatives were established by elemental and spectral data. J. Heterocyclic Chem., (2009).