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A simple, efficient, one‐pot three‐component domino synthesis of Hantzsch pyridines under solvent‐free condition
Author(s) -
NasrEsfahani Masoud,
Karami Bahador,
Behzadi Masoume
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.175
Subject(s) - chemistry , domino , pyridine , organic chemistry , combinatorial chemistry , simple (philosophy) , chlorate , component (thermodynamics) , solvent , reaction conditions , catalysis , philosophy , physics , epistemology , thermodynamics
In this article, efficient and simple preparation of Hantzsch pyridine derivatives by reaction of various aldehydes and β‐dicarbonyls in the presence of ammonium chlorate under solvent‐free condition at 80°C is reported. The advantages of this system are the one‐step procedure, high yields of the products, and the ability to carry out large‐scale reactions. J. Heterocyclic Chem., (2009).