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A Mild and Efficient Method to Functionalize Azines (Quinoline, Isoquinoline, and Phenanthridine) Using Acetylenic Esters and Heterocyclic NH or 1,3‐Dicarbonyl Compounds
Author(s) -
Nassiri Mahmoud
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1749
Subject(s) - phenanthridine , chemistry , isoquinoline , quinoline , benzotriazole , indole test , heterocyclic compound , organic chemistry , medicinal chemistry
One‐pot reactions involving azines (quinoline, isoquinoline, and phenanthridine), with acetylenic esters in the presence of heterocyclic NH compounds (benzotriazole, 2‐methylbenzimidazole, 2‐benzoxazolinone, 6‐chlorobenzoxazolinone, maleimide, indole, and 2‐methylindole) or 1,3‐dicarbonyl compound such as 5,5‐dimethyl‐1,3‐cyclohexadione, are described. The reactions proceeded smoothly at RT, and with excellent yields. The structures of the synthesized compounds have been characterized by the elemental analyses and spectral studies.