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Silica Sulfuric Acid‐Catalyzed Five‐component Efficient Synthesis of Five‐Substituted Tetrahydropyridines
Author(s) -
Zhang Xiaoxiao,
Wan Yu,
Pang Liling,
Wang Haiying,
Zhao Lingling,
Wang Chao,
Hang Shu Ying,
Liu Gui Xiang,
Chen LiangFeng,
Wu Hui
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1744
Subject(s) - chemistry , aniline , aldehyde , sulfuric acid , catalysis , ring (chemistry) , condensation , organic chemistry , component (thermodynamics) , silica gel , medicinal chemistry , physics , thermodynamics
A highly atom‐economic one‐pot synthesis of five‐substituted tetrahydropyridines via a five‐component condensation of two equivalents of aromatic aldehyde, two equivalents of aromatic aniline, and one equivalent of β‐keto ester catalyzed by silica sulfuric acid is reported. In this reaction, up to five new bonds and one new ring were formed in one pot with water as the only one by‐product.