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Silica gel‐supported sulfuric acid catalyzed synthesis of 1,5‐benzodiazepine derivatives
Author(s) -
Shobha D.,
Chari M. Adharvana,
Mukkanti K.,
Ahn K. H.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.174
Subject(s) - chemistry , acetonitrile , catalysis , sulfuric acid , silica gel , environmentally friendly , solvent , reaction conditions , organic chemistry , combinatorial chemistry , ecology , biology
ilica gel‐supported sulfuric acid has been found to be an efficient catalyst for the synthesis of 1,5‐benzodiazepines from o ‐phenylenediamine and ketones in acetonitrile solvent. This method is simple, effective, and environmentally friendly and gives better yields. Compared to the classical reaction conditions, this new method consistently has the advantage of excellent yields (80–97%) and short reaction time (30–150 min) at room temperature. J. Heterocyclic Chem., (2009).