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Synthesis of halogenoindirubins
Author(s) -
Tanoue Yasuhiro,
Ikoma Yousuke,
Kai Norihisa,
Nagai Takeshi
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.172
Subject(s) - chemistry , yield (engineering) , methanol , nuclear magnetic resonance spectroscopy , organic chemistry , metallurgy , materials science
The synthesis of halogenoindirubins was attempted. The reaction of 3‐acetoxy‐6‐bromoindole ( 5 ) with 6‐bromoisation ( 10 ) in methanol with Na 2 CO 3 produced 6‐bromo‐6′‐fluoroindirubin ( 11 ) in 80% yield. Its structure determination was mainly undertaken using 1 H NMR spectroscopy. A similar reaction gave 6′‐bromoindirubin ( 12 ) and 6‐bromoindirubin ( 3 ) in moderate yields. J. Heterocyclic Chem., (2009).