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Synthesis of New Chromeno[4,3‐ b ]pyrazolo[4,3‐ e ]pyridines Derivatives with Antimicrobial Evaluation
Author(s) -
ElEssawy Farag A.,
ElEtrawy AbdAllah. Sh.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1687
Subject(s) - chemistry , cyanoacetamide , pyridine , hydrazine (antidepressant) , hydrate , sodium hydroxide , medicinal chemistry , organic chemistry , derivative (finance) , antimicrobial , aldehyde , catalysis , chromatography , financial economics , economics
A series of 2‐oxo‐2,5‐dihydro‐1 H ‐chromeno[4,3‐ b ]pyridine derivatives were obtained by using a one‐pot three component reaction of 2,2‐disubstituted chroman‐4‐one with aromatic aldehydes and 2‐cyanoacetamide in the presence of sodium hydroxide under solvent‐free conditions. Heating chromenopyridine derivatives with phosphoryl chloride gave the corresponding chloro derivatives. The reaction of the chloro derivatives with hydrazine hydrate afforded dihydrochromeno[4,3‐ b ]pyrazolo[4,3‐ e ]pyridines derivatives. Condensation of the dimethyl derivative compound with the aromatic aldehydes gave 8‐Arylideneamino‐6,6‐dimethyl‐10 H ‐chromeno[4,3‐ b ]pyrazolo[4,3‐ e ]pyridine.