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Synthesis, Characterization, and Antimicrobial Screening of Ethylene‐Spaced Bis‐heterocycles
Author(s) -
Babul Reddy A.,
Hymavathi R. V.,
Narayana Swamy G.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1675
Subject(s) - chemistry , antimicrobial , ethylene , azide , elemental analysis , antifungal , amine gas treating , propargyl , halide , mass spectrum , carbon 13 nmr , combinatorial chemistry , proton nmr , organic chemistry , ion , catalysis , medicine , dermatology
A new class of ethylene‐spaced bis‐heterocycles that was synthesized in a simple and efficient method from the one‐pot, three‐component reaction of amine 2 , propargyl halide 3 , and indolyl azide 1 in water is described. The identities of these compounds were confirmed following elemental analysis, IR, 1 H, 13 C NMR, and mass spectral studies. All the title compounds exhibited pronounced in vitro antibacterial and antifungal activities.