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Synthesis of Some New Pyridine and Pyrimidine Derivatives Containing Benzothiazole Moiety
Author(s) -
Mohamed Khaled S.,
Abdulaziz Nayra M.,
Fadda Ahmed A.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1672
Subject(s) - chemistry , benzothiazole , acetonitriles , pyridazine , moiety , pyrimidine , pyridine , thiouracil , stereochemistry , medicinal chemistry , organic chemistry , acetonitrile , medicine , thyroid
A variety of pyridine and pyrimidine rings incorporating benzothiazole moiety were synthesized by reaction of 1‐(2‐benzothiazolyl)‐1‐cyano‐3‐chloroacetone ( 1 ) with 2‐pyridone, 2‐thioxopyridine, thiouracil, and 2‐thioxopyrimidine derivatives to give compounds 7,9‐dimethylfuro[2,3‐ b :4,5‐ b ′]dipyridin‐4‐ol 5 , 4, 6‐diphenylthieno[2,3‐ b ]pyridin‐2‐yl 9 , 2‐(benzo[ d ]thiazol‐2‐yl)‐2‐(7‐substituted‐5‐oxo‐5 H ‐thiazolo[3,2‐ a ]pyrimidin‐3‐yl)acetonitriles 12a and 12b , pyrimido[2,1‐ b ][1,3]thiazepine‐3‐carboxamide 15 , and benzo[4,5]thiazolo[3,2‐ b ]pyridazine‐3‐one 20 , respectively.