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An efficient and convenient multicomponent reaction for the synthesis of 2‐methyl‐4,6‐diarylpyrimidine under solvent‐free conditions
Author(s) -
Rong Liangce,
Han Hongxia,
Jiang Hong,
Dai Yisi,
Zhuang Mengjie,
Cao Minxiang,
Tu Shujiang
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.167
Subject(s) - chemistry , sodium hydroxide , environmentally friendly , solvent , organic chemistry , hydrochloride , reaction conditions , combinatorial chemistry , catalysis , ecology , biology
AbstractAn efficient and convenient method for the preparation of 2‐methyl‐4,6‐diarylpyrimidine derivatives by the multicomponent reactions of aromatic aldehydes, aromatic ketones, and acetamidine hydrochloride in the presence of sodium hydroxide under solvent‐free conditions was reported. This method has the advantages of excellent yields, mild reaction conditions, easy workup, and environmentally friendly procedure. J. Heterocyclic Chem., (2009).