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DBU‐catalyzed Multicomponent Synthesis: Facile Access of 4,5,6,9‐Tetrahydro‐pyrido[3,2‐ c ]quinolines
Author(s) -
Chaniyara Ravi,
Thakrar Shailesh,
Kakadiya Rajesh,
Marvania Bhavin,
Detroja Dilip,
Vekariya Nikhil,
Upadhyay Kuldip,
Manvar Atul,
Shah Anamik
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1662
Subject(s) - chemistry , catalysis , nucleophile , combinatorial chemistry , proton nmr , reaction conditions , medicinal chemistry , stereochemistry , organic chemistry
An efficient synthesis of 4 H ,5 H ,6 H ,9 H ‐pyrido[ ij ]pyrano[3,2‐ c ]quinolines 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l , 4m , 4n , 4o , 4p , 4q , 4r , 4s , 4t as well as spiro compound 6 was achieved via multicomponent approach by using DBU as a nucleophilic catalyst under the remarkably mild reaction conditions. The structures of the compounds were characterized by 1 H NMR, 13 C NMR, and mass spectral analysis. An attractive feature of this inexpensive protocol includes facile synthesis, shorter reaction time, ease of work‐up, large number of functional group tolerance, and good to excellent yields with high purity.