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An Efficient Ultrasound‐Assisted Synthesis of N ‐Alkyl Derivatives of Carbazole, Indole, and Phenothiazine
Author(s) -
Zhao Sanhu,
Kang Jin,
Du Yuting,
Kang Jingyan,
Zhao Xiaoni,
Xu Yinfeng,
Chen Ruixi,
Wang Qianqian,
Shi Xitao
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1652
Subject(s) - phenothiazine , chemistry , carbazole , indole test , alkylation , alkyl , potassium hydroxide , yield (engineering) , nitrogen atom , medicinal chemistry , base (topology) , organic chemistry , combinatorial chemistry , catalysis , medicine , mathematical analysis , materials science , mathematics , metallurgy , pharmacology
Heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen such as carbazole, indole, and phenothiazine can be efficiently alkylated in DMSO or N , N ‐DMF under ultrasonic irradiation in the presence of potassium hydroxide as a base. In almost all cases, a dramatic reduction of the reaction time results and a clear yield increase accompanied by an improved quality of the products occurs.
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