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Efficient Method for the Synthesis of Functionalized Basic Maleimides
Author(s) -
Salewska Natalia,
Milewska Maria J.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1651
Subject(s) - chemistry , imide , maleic anhydride , diamine , diels–alder reaction , catalysis , organic chemistry , condensation , double bond , maleimide , combinatorial chemistry , polymer chemistry , copolymer , polymer , physics , thermodynamics
A three‐step procedure involving Diels–Alder condensation of maleic anhydride with furane, formation of N ‐substituted imide upon reaction with appropriate diamine, and a final retro Diels–Alder regeneration of the maleic carbon–carbon double bond is proposed for an unequivocal synthesis of N ‐substituted basic maleimides. The novel method is characterized by mild reaction conditions, easy work‐up, high yields, and no need for additional catalysis .
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