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Synthesis of New 2,4‐Diaryl‐6‐methyl‐5‐nitropyrimidines as Antibacterial and Antioxidant Agents
Author(s) -
Sura Mallikarjun Reddy,
Peddiahgari Vasu Govardhana Reddy,
Bhoomireddy Rajendra Prasad Reddy,
Vadde Rama Krishna
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1645
Subject(s) - chemistry , bacillus subtilis , antioxidant , klebsiella pneumoniae , antibacterial activity , staphylococcus aureus , bacteria , ferrocene , escherichia coli , aryl , organic chemistry , biochemistry , alkyl , electrode , gene , electrochemistry , genetics , biology
A new series of 2,4‐diaryl‐6‐methyl‐5‐nitropyrimidines ( 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i ) were synthesized in good yields by Suzuki–Miyaura coupling of 2,4‐dichloro‐6‐methyl‐5‐nitropyrimidine ( 3 ) with various aryl boronic esters ( 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i ) in the presence of 1,1′‐ bis(diphenylphosphino)ferrocene dichloropalladium(II) (Pd(dppf) 2 Cl 2 ). Further, antibacterial and antioxidant properties were screened for the title compounds 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i . Most of the compounds possessed significant activity against Gram‐positive bacteria Staphylococcus aureus and Bacillus subtilis and Gram‐negative bacteria Escherichia coli and Klebsiella pneumoniae . The antioxidant activity of the title compounds showed significant antioxidant activity when compared with vitamin C.

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