Synthesis of Thiazolidin‐4‐ones from Substituted (Ylidene)hydrazinecarbothioamides and Dimethyl Acetylenedicarboxylate | Zendy

Hassan Alaa A. | Zendy; Aly Ashraf A. | Zendy; ElShaieb Kamal M. A. | Zendy; Bedair Tarek M. I. | Zendy; Bräse Stefan | Zendy; Brown Alan B. | Zendy

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Synthesis of Thiazolidin‐4‐ones from Substituted (Ylidene)hydrazinecarbothioamides and Dimethyl Acetylenedicarboxylate

Author(s) -

Hassan Alaa A.,

Aly Ashraf A.,

ElShaieb Kamal M. A.,

Bedair Tarek M. I.,

Bräse Stefan,

Brown Alan B.

Publication year - 2014

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1642

Subject(s) - dimethyl acetylenedicarboxylate , chemistry , yield (engineering) , nucleophile , medicinal chemistry , conjugated system , organic chemistry , cycloaddition , catalysis , polymer , materials science , metallurgy

Conjugated substituted (ylidene)hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate to give substituted [(ylidene)hydrazono)‐4‐oxothiazolidin‐5‐ylidene]acetates; several mechanistic options involving nucleophilic interaction are presented.

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