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An Efficient Microwave‐Assisted Synthesis and Antimicrobial Activity of Novel 2‐Amino 3‐Cyano Pyridine Derivatives using Two Reusable Solid Acids as Catalysts
Author(s) -
Thakrar Shailesh,
Bavishi Abhay,
Radadiya Ashish,
Vala Hardevsinh,
Parekh Shrey,
Bhavsar Dhairya,
Chaniyara Ravi,
Shah Anamik
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1641
Subject(s) - chemistry , malononitrile , ammonium acetate , catalysis , pyridine , antimicrobial , coumarin , montmorillonite , proton nmr , environmentally friendly , carbon 13 nmr , antifungal , organic chemistry , reaction conditions , combinatorial chemistry , nuclear chemistry , medicine , ecology , high performance liquid chromatography , dermatology , biology
Two solid acids, Fe 3+ K‐10 montmorillonite clay and HY‐zeolite, have been employed efficiently for synthesis of 2‐amino 3‐cyano pyridines 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l , 4m , 4n , 4o , 4p , 4q , 4r , 4s , 4t , 4u , 4v , 4w , 4x by multicomponent reaction of 3‐acetyl 4‐hydroxy coumarin 1a , 1b , 1c , 1,3‐diphenyl‐1 H ‐pyrazole‐4‐carbaldehyde 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , malononitrile 3 , and ammonium acetate. Both the catalysts are recoverable and recyclable. The main significant of this procedure is short reaction time, high yields, easy workup procedure, and being environmentally friendly. The structures of all the compounds have been well characterized by IR, 1 H NMR, 13 C NMR, and mass spectral data. All the synthesized compounds were screened for their antimicrobial and antifungal activities.