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Facile Synthesis of Diarylpyrazolo[1,5‐ a ]pyrimidine from Isoflavones
Author(s) -
Yang Junling,
Zhang Zunting,
He Qing
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1633
Subject(s) - chemistry , sodium methoxide , isoflavones , pyrimidine , elemental analysis , organic chemistry , proton nmr , combinatorial chemistry , stereochemistry , methanol , biochemistry
A new facile and straightforward method for synthesis of 2‐methyl‐6,7‐diphenyl‐ pyrazolo[1,5‐ a ]pyrimidines has been described. The cyclocondensation of isoflavones with 3‐amino‐5‐methylpyrazole in the presence of sodium methoxide gave fused 2‐methyl‐6,7‐diphenylpyrazolo[1,5‐ a ]pyrimidines in moderate to good yields. A series of 20 new compounds were obtained and characterized by FT‐IR, NMR, and elemental analysis.