Utilization of 2‐Chloronicotinonitrile in the Syntheses of Novel Fused Bicyclic and Polynuclear Heterocycles of Anticipated Antitumor Activity | Zendy

Hamama Wafaa S. | Zendy; Waly Mohamed A. | Zendy; ElHawary Ibrahim I. | Zendy; Zoorob Hanafi H. | Zendy

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Utilization of 2‐Chloronicotinonitrile in the Syntheses of Novel Fused Bicyclic and Polynuclear Heterocycles of Anticipated Antitumor Activity

Author(s) -

Hamama Wafaa S.,

Waly Mohamed A.,

ElHawary Ibrahim I.,

Zoorob Hanafi H.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1631

Subject(s) - bicyclic molecule , chemistry , thienopyridine , pyridine , combinatorial chemistry , ring (chemistry) , stereochemistry , organic chemistry , biochemistry , aspirin , clopidogrel

Some of synthetic bicyclic and polynuclear heterocyclic compounds based on pyridine scaffold were tested as in vitro antitumor agents , and these compounds found to exhibit interesting activities. Fused heterocycles containing sulfur such as thienopyridine, pyridothiazine, and some related fused heterocycles as new ring systems were achieved. Bicyclic thienopyridine 6 and pyrido[3,2‐ e ][1,3]thiazin‐4(3 H )‐one 7 exhibited good antitumor activities compared with 5‐fluorouracil.

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