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Utilization of 2‐Chloronicotinonitrile in the Syntheses of Novel Fused Bicyclic and Polynuclear Heterocycles of Anticipated Antitumor Activity
Author(s) -
Hamama Wafaa S.,
Waly Mohamed A.,
ElHawary Ibrahim I.,
Zoorob Hanafi H.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1631
Subject(s) - bicyclic molecule , chemistry , thienopyridine , pyridine , combinatorial chemistry , ring (chemistry) , stereochemistry , organic chemistry , biochemistry , aspirin , clopidogrel
Some of synthetic bicyclic and polynuclear heterocyclic compounds based on pyridine scaffold were tested as in vitro antitumor agents , and these compounds found to exhibit interesting activities. Fused heterocycles containing sulfur such as thienopyridine, pyridothiazine, and some related fused heterocycles as new ring systems were achieved. Bicyclic thienopyridine 6 and pyrido[3,2‐ e ][1,3]thiazin‐4(3 H )‐one 7 exhibited good antitumor activities compared with 5‐fluorouracil.