Premium
An Efficient and Green Synthesis of 6‐Amino‐3‐phenyl‐4‐aryl‐1,4‐dihydropyrano [2,3‐ c ]pyrazole‐5‐carbonitrile Derivatives under Ultrasound Irradiation in Aqueous Medium
Author(s) -
Zou Yi,
Hu Yu,
Liu Hai,
Shi DaQing
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1627
Subject(s) - malononitrile , chemistry , pyrazole , hydrazine (antidepressant) , aryl , catalysis , aqueous medium , yield (engineering) , combinatorial chemistry , aqueous solution , organic chemistry , chromatography , alkyl , materials science , metallurgy
A facile and eco‐friendly approach for the synthesis of 6‐amino‐3‐phenyl‐4‐aryl‐1,4‐dihydropyrano[2,3‐ c ]pyrazole‐5‐carbonitrile derivatives via four‐component reaction of hydrazine, ethyl 3‐oxo‐3‐phenylpropanoate, aldehydes, and malononitrile is described. The reaction is performed in water, without using any catalyst, and under ultrasound irradiation. The developed sonochemical‐assisted multi‐component reaction provides an improved and accelerated conversion when compared with conventional procedure.