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Microwave‐enhanced Efficient Synthesis of Some Polyfunctional Pyridazines
Author(s) -
Kumar Jangid M.,
Yadav T.,
Yadav A. K.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1623
Subject(s) - ionic liquid , hexafluorophosphate , chemistry , tetrafluoroborate , pyridazine , hydroxide , organic chemistry , green chemistry , microwave , combinatorial chemistry , catalysis , physics , quantum mechanics
Microwave‐enhanced highly efficient protocol for the synthesis of polyfunctional pyridazines beginning from 3,6‐dichloropyridazine in environmentally benign ionic liquids have been developed. The products obtained were 3‐amino‐6‐chloropyridazine, 3,6‐diaminopyridazine, and 3‐chloro‐6‐methoxypyridazine. These derivatives were then be converted to a variety of polyfunctional pyridazine derivatives. The ionic liquids used were 1‐ n ‐butyl‐3‐methylimidazolium hydroxide/tetrafluoroborate/hexafluorophosphate and 1,3‐di‐ n ‐butylimidazolium hydroxide. This powerful strategy is less time‐consuming green methodology. The ionic liquid employed may be recovered and recycled.