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Synthesis of Novel Pyrano[2,3‐ b ]pyridines from α,α′‐Bis(substituted‐benzylidene)cycloalkanones
Author(s) -
Bigdeli Mohammad Ali,
Marjani Katayon,
Farokhi Elinaz,
Sheikhhosseini Enayatollah,
Ghazanfari Dadkhoda
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1612
Subject(s) - chemistry , malononitrile , catalysis , tacrine , organic chemistry , medicinal chemistry , acetylcholinesterase , enzyme
In this paper, we describe a two‐step synthesis of a series of tacrine analogues. In the first step, α,α'‐bis(substituted‐benzylidene)cycloalkanones are reacted with malononitrile to afford 2‐amino‐3‐cyano‐4 H ‐pyrans. The second step involves the conversion of pyrans to pyrano[2,3‐ b ]pyridines with the use of AlCl 3 as catalyst.