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An efficient and direct synthesis of 2‐thiopyridines via microwave‐assisted three‐component reaction
Author(s) -
Wang XingHan,
Cao XuDong,
Tu ShuJiang,
Zhang XiaoHong,
Hao WenJuan,
Yan Shu,
Wu ShanShan,
Han ZhengGuo,
Shi Feng
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.161
Subject(s) - chemistry , malononitrile , yield (engineering) , component (thermodynamics) , microwave irradiation , combinatorial chemistry , catalysis , organic chemistry , materials science , physics , metallurgy , thermodynamics
A series of 2‐ p ‐tolylthiopyridine derivatives was directly synthesized via three‐component reactions of chalcones, malononitrile, and 4‐methylbenzenethiol catalyzed by Et 3 N in DMF under microwave irradiation. It is an efficient and promising synthetic strategy to construct 2‐thiopyridine skeleton with the advantage of short time, excellent yield, and convenient operation. J. Heterocyclic Chem., (2009).