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One‐Pot, Four‐Component Synthesis of Novel Spiro[indeno[2,1‐ b ]quinoxaline‐11,4′‐pyran]‐2′‐amines
Author(s) -
Hasaninejad Alireza,
Golzar Nooshin,
Zare Abdolkarim
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1604
Subject(s) - quinoxaline , chemistry , ninhydrin , pyran , component (thermodynamics) , organic chemistry , multi component reaction , medicinal chemistry , combinatorial chemistry , catalysis , biochemistry , amino acid , physics , thermodynamics
A one‐pot, four‐component reaction for the efficient synthesis of novel spiro[indeno[2,1‐ b ]quinoxaline‐11,4′‐pyran]‐2′‐amines by using InCl 3 is described. The syntheses are achieved by reacting ninhydrin with 1,2‐diaminobenzenes to give indenoquinoxalines, which are trapped in situ by alkyl malonates and various α‐methylencarbonyl compounds through cyclization, providing multifunctionalized spiro‐substituted indeno[2,1‐ b ]quinoxaline‐11,4′‐pyran‐2′‐amines.