Reactions of 2‐Methylchromones with Cyanoacetamides and Ethyl Cyanoacetate. Synthesis of 6‐(2‐Hydroxyaryl)‐4‐methyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles and 7‐Hydroxy‐6‐imino‐9‐methyl‐6 H ‐benzo[ c ]chromene‐8‐carbonitriles | Zendy

Sosnovskikh Vyacheslav Ya. | Zendy; Anufriev Viktor A. | Zendy; Safrygin Alexander V. | Zendy; Eltsov Oleg S. | Zendy

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Reactions of 2‐Methylchromones with Cyanoacetamides and Ethyl Cyanoacetate. Synthesis of 6‐(2‐Hydroxyaryl)‐4‐methyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles and 7‐Hydroxy‐6‐imino‐9‐methyl‐6 H ‐benzo[ c ]chromene‐8‐carbonitriles

Author(s) -

Sosnovskikh Vyacheslav Ya.,

Anufriev Viktor A.,

Safrygin Alexander V.,

Eltsov Oleg S.

Publication year - 2013

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1601

Subject(s) - chemistry , cyanoacetamide , ethyl cyanoacetate , sodium ethoxide , ethanol , malononitrile , dihydropyridine , organic chemistry , medicinal chemistry , calcium , catalysis

Although 2‐methylchromones react with cyanoacetamide and N ‐methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6‐(2‐hydroxyaryl)‐4‐methyl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles, their reactions with ethyl cyanoacetate under the same conditions took an entirely different course and gave 7‐hydroxy‐6‐imino‐9‐methyl‐6 H ‐benzo[ c ]chromene‐8‐carbonitriles.

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