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Microwave‐Assisted Three‐Component Reactions Leading to Pyrano‐Fused Pyrazolo[3,4‐ b ]pyridines
Author(s) -
Xu BiHui,
Tu ManSu,
Liu YinPing,
Jiang Bo,
Wang XingHang,
Tu ShuJiang
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1597
Subject(s) - chemistry , pyridine , tetrahydropyran , amine gas treating , component (thermodynamics) , aryl , ring (chemistry) , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , physics , alkyl , thermodynamics
A series of pyrano‐fused pyrazolo[3,4‐ b ]pyridine derivatives with an aryl group presenting the 2‐position of the pyridine nucleus have been synthesized by microwave‐assisted three‐component reactions of aldehydes, tetrahydropyran‐4‐one, and 3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐amine in HOAc. This method is very efficient because of short reaction times and easy work‐up, and it provides an efficient and promising synthetic strategy for the construction of the tricyclic pyrano‐fused pyrazolo[3,4‐ b ]pyridine skeleton.