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Synthesis of Substituted Pyridyl‐Pyrimidines as Potential Protein–Protein Interaction Inhibitors
Author(s) -
Islam Shahid,
Firestine Steven M.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1595
Subject(s) - chemistry , pyrimidine , yield (engineering) , combinatorial chemistry , transformation (genetics) , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy , gene
An efficient synthetic method for the preparation of pyridyl‐pyrimidines as potential inhibitors of protein–protein interactions is described. The key transformation is the reaction of a pyrimidine enaminone with phenyl ethyl acetate and NH 4 OAc to yield the desired pyridyl‐pyrimidine.