Synthesis of Spirocyclic and Tricyclic Isoxazoline via  1,3‐Dipolar Cycloaddition Reactions | Zendy

Gul Melek | Zendy; Tutar Ahmet | Zendy

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Synthesis of Spirocyclic and Tricyclic Isoxazoline via 1,3‐Dipolar Cycloaddition Reactions

Author(s) -

Gul Melek,

Tutar Ahmet

Publication year - 2014

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1592

Subject(s) - chemistry , tricyclic , bicyclic molecule , camphene , nitrile , cycloaddition , aryl , bioassay , organic chemistry , 1,3 dipolar cycloaddition , stereochemistry , chromatography , catalysis , biology , essential oil , genetics , alkyl

1,3‐Dipolar cycloadditions of the bicyclic monoterpenes ( S )‐(−)‐camphene ( 1 ), ( R )‐(+)‐a‐pinene ( 2 ), and ( S )‐(−)‐b‐pinene ( 3 ) with aryl and heteroaryl nitrile oxides afforded new spirocyclic and tricyclic isoxazoline derivatives 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 whose biological activities were evaluated in bioassay studies.

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