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KI‐VO(acac) 2 ‐H 2 O 2 ‐AcOH, A New Iodinating System for Selective Iodination at C‐5 Position of Activated Pyrimidinediones: A Combined Experimental and Density Functional Study
Author(s) -
Saikia Lakhinath,
Talukdar Dhrubajyoti,
Deka Ramesh C.,
Thakur Ashim J.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1575
Subject(s) - chemistry , reactivity (psychology) , halogenation , acetic acid , aqueous solution , organic chemistry , nuclear chemistry , medicinal chemistry , inorganic chemistry , medicine , alternative medicine , pathology
KI‐VO(acac) 2 ‐H 2 O 2 in aqueous ethanolic medium with acetic acid as additive has been found to iodinate pyrimidinediones and aromatic amines. The methodology is mild, efficient, and environmentally benign. Density functional theory‐based reactivity parameters support the experimentally observed reactivity of pyrimidinedione derivatives.