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The Synthesis of Some New ( S )‐1‐Aryl‐ N ‐(1‐hydroxy‐3‐phenylpropan‐2‐yl)‐5‐methyl‐1 H ‐1,2,3‐triazole‐4‐carboxamide
Author(s) -
Shen G.L.,
Chen Z.B.,
Wu Z.F.,
Dong H.S.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1567
Subject(s) - chemistry , intramolecular force , intermolecular force , hydrogen bond , aryl , carboxamide , triazole , molecule , proton nmr , crystallography , bond length , stereochemistry , medicinal chemistry , crystal structure , organic chemistry , alkyl
Some new ( S )‐1‐aryl‐ N ‐(1‐hydroxy‐3‐phenylpropan‐2‐yl)‐5‐methyl‐1 H ‐1,2,3‐triazole‐4‐carboxamides 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j have been synthesized and established by 1 H and 13 C NMR, IR, MS spectra, CHN analyses, and x‐ray diffraction crystallography. The molecular conformation and packing is stabilized by interactions of intermolecular H‐bond O2’‐H2'···O1, O2‐H2···O1’ and intramolecular H‐bond N4’‐H4'N···N3’, N4’‐H4'N···O2’, N4‐H4N···N3, N4‐H4N···O2. The two rings of five numbers were formed by H‐bond in a molecular.