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Synthesis of 1 H ‐Imidazoles Catalyzed by Cu‐Nanoparticle and Its Physicochemical Properties
Author(s) -
Pagadala Ramakanth,
Gandhare Nilesh V.,
Kusampally Uppalaiah,
Jetti Venkateshwarlu,
Meshram Jyotsna S.,
Juneja H. D.
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1551
Subject(s) - chemistry , dispersity , nanoparticle , carbon 13 nmr , elemental analysis , aryl , proton nmr , molecule , solvent , polyol , imidazole , nuclear chemistry , organic chemistry , combinatorial chemistry , chemical engineering , alkyl , engineering , polyurethane
Series of 1‐arylmethyl‐4, 5‐dihydro‐2‐aryl‐1 H ‐imidazole were synthesized expeditiously in good yields from 1,2‐diaminoethane and aromatic aldehydes in the presence of Cu nanoparticle under microwave irradiation in solvent‐free method. Monodisperse spherical Cu nanoparticles with a diameter range of 45 ± 8 nm were synthesized by polyol process. The particle size and elemental structure of copper nanoparticles were confirmed by XRD data and was found to be having a face‐centered cubic structure. The resulting substituted imidazoles have been studied in the achievement of degree of drug absorption enhancement as well as the potential associated toxicity on the basis of hypothetical antibacterial pharmacophores and structures that were designed to interact with both of gram‐positive and gram‐negative bacteria. All the synthesized molecules were characterized on the basis of 1H NMR, 13C NMR, mass spectrometry , and elemental data.