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Synthesis of 9‐Allyl‐10‐hydroxycamptothecin via Suzuki Reaction
Author(s) -
Luo Yu,
Yu Shanbao,
Huang Qingqing,
Lu Wei
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1549
Subject(s) - chemistry , yield (engineering) , camptothecin , combinatorial chemistry , high performance liquid chromatography , organic chemistry , metallurgy , materials science
A facile and eco‐friendly approach for synthesizing 9‐allyl‐10‐hydroxycamptothecin ( 2 ), a key intermediate for the preparation of camptothecin analogs, is described. The product was obtained in good yield and high purity (≥99% HPLC) under mild Suzuki reaction condition.