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N ‐Fluorobenzenesulfonimide as Catalyst for the Three‐Component Synthesis of Isoquinuclidines
Author(s) -
Wu D.,
He YH.,
Deng X.,
Guan Z.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1544
Subject(s) - chemistry , catalysis , component (thermodynamics) , stereoselectivity , organic chemistry , combinatorial chemistry , thermodynamics , physics
N ‐Fluorobenzenesulfonimide was used for the first time as a catalyst to carry out the three‐component synthesis of isoquinuclidines with the use of various cyclohexenone ( 1 ), benzaldehydes ( 2 ), and anilines ( 3 ). The yields up to 80% and the endo/exo stereoselectivity ratios up to 19:81 were achieved.
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