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Facile Synthesis of Aryl‐Pyridyl, Pyridazinyl, Pyrazinyl, and Triazinyl Acetonitriles
Author(s) -
Farahat A. A.,
Boykin D. W.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1535
Subject(s) - acetonitriles , chemistry , acetonitrile , pyridazine , pyrazine , pyridine , nucleophile , medicinal chemistry , halogen , organic chemistry , catalysis , alkyl
Dihalo pyridine, pyrazine, and pyridazine analogues were converted to the corresponding monohalo acetonitrile analogues through nucleophilic displacement of the halogen with the anion of tert ‐butyl cyanoacetate. The monohalo acetonitriles reacted under Suzuki or Stille conditions to form the title compounds.