Premium
A Facile and Efficient Solid Supported, One‐Pot Synthesis of Functionalized Piperidine Derivatives Catalyzed by Amberlite IRA400‐Cl Resin/I 2 /KI via Multicomponent Reaction
Author(s) -
Harichandran Gurusamy,
Amalraj Savarimuthu David,
Shanmugam Ponnusamy
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1516
Subject(s) - amberlite , piperidine , chemistry , catalysis , yield (engineering) , one pot synthesis , reaction conditions , organic chemistry , combinatorial chemistry , adsorption , materials science , metallurgy
A facile and efficient one‐pot, solid supported synthesis of functionalized piperidine derivatives catalyzed by Amberlite IRA400‐Cl resin/I 2 /KI via a multicomponent reaction of various aldehydes, aromatic amines, and 1,3‐dicarbonyl compounds has been achieved. The reaction has been carried out in a one‐pot reaction and Amberlite resin as a solid supported catalyst at room temperature. Shorter reaction time, easy workup, yield, and mild reaction condition make the novel synthetic strategy both practical and attractive.