Premium
New access to the one‐pot solvent‐free synthesis of 4,5‐dihydro‐pyrido[2,3‐ b ][1,4]diazepines and 2,3‐dihydro‐benzo[ b ][1,4]diazepines by microwave irradiation
Author(s) -
Goswami Shyamaprosad,
Hazra Anita,
Jana Subrata
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.148
Subject(s) - chemistry , aryl , solvent , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
AbstractA series of diversely substituted pyridodiazepines and benzodiazepines have been synthesized in solvent and catalyst free microwave condition from aryl/heteroaryl diamines and β‐aryl vinyl ketones. The yields of the reactions varied with the substituents attached to the aryl/heteroaryl diamines. This common protocol is equally effective for the synthesis of pyridodiazepines and benzodiazepines with pharmacological interest, though in case of pyridodiazepines required time is comparatively higher than benzodiazepines. J. Heterocyclic Chem., (2009).