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Friedel‐Crafts heteroarylation of (hetero)arenes: A facile entry to 4‐(hetero)aryl quinazolines and quinolines
Author(s) -
Kumar Shailesh,
Sahu Devi Prasad
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.144
Subject(s) - chemistry , aryl , anhydrous , quinazoline , combinatorial chemistry , chloride , friedel–crafts reaction , medicinal chemistry , organic chemistry , alkyl , catalysis
Anhydrous AlCl 3 ‐mediated heteroarylation of various arenes and heteroarenes with 2,4‐dichloro‐quinazoline ( 1 ) and 4‐chloroquinoline ( 4 ) afforded exclusively 4‐aryl/heteroarylquinazolines ( 3 ) and 4‐aryl/heteroarylquinolines ( 5 ), respectively. Compared with the available synthetic protocols, aluminum chloride induced CC bond formation is direct and convenient to access bis‐(hetero)aryl quinazolines and quinolines. The products were obtained in good to excellent yields by this method. J. Heterocyclic Chem., (2009).