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Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives
Author(s) -
Xue Na,
Zhou Yuhan,
Wang Guowei,
Miao Weirong,
Qu Jingping
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.134
Subject(s) - benzoxazole , chemistry , protoporphyrinogen oxidase , acylation , bioassay , nitration , methylation , organic chemistry , benzimidazole , ring (chemistry) , combinatorial chemistry , biochemistry , enzyme , biology , gene , genetics , catalysis
AbstractIn recent years, protoporphyrinogen oxidase (Protox) inhibitor herbicides are developed rapidly, because of this type of herbicides shows high herbicidal activity and low toxicity. In this paper, we prepared a series of new substituted pyrazolyl benzoxazole derivative, which were synthesized from 4‐fluorophenol, via a serial of reactions included chlorination , acylation , condensation , ring closure, methylation , nitration , and so on. All the structures are confirmed by 1 H NMR, MS and element analysis. Preliminary bioassay shows that most substituted pyrazolyl benzoxazole derivatives exhibit high herbicidal activity to the tested gramineous weeds and latifoliate weeds. J. Heterocyclic Chem., (2010).