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Synthesis, characterization, and anti‐inflammatory evaluation of 1,2,4‐oxadiazoles combined with thiosemicarbazide and 1,3,4‐oxadiazole moieties
Author(s) -
dos Santos Filho José M.,
de Lima José G.,
Leite Lúcia F. C. C.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.133
Subject(s) - chemistry , oxadiazole , phenyl isothiocyanate , isothiocyanate , ring (chemistry) , combinatorial chemistry , anti inflammatory , medicinal chemistry , stereochemistry , organic chemistry , pharmacology , medicine
The reaction of 1,2,4‐oxadiazole carbohydrazides 1a , 1b , 1c , 1d , 1e , 1f , 1g , 1h with phenyl isothiocyanate led to an unexpected ring cyclisation of the thiosemicarbazide derivatives 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , giving compounds 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h as side products. These two new series were preliminarily evaluated for their anti‐inflammatory activity, using the carrageenin induced edema protocol. J. Heterocyclic Chem., (2009).