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Solvent‐free microwave‐assisted synthesis of 1 H ‐indole‐2, 3‐dione derivatives
Author(s) -
Singh Ashish Kumar,
Shukla Sudhish Kumar,
Ahamad Ishtiaque,
Quraishi M. A.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.131
Subject(s) - chemistry , isatin , yield (engineering) , elemental analysis , microwave , indole test , organic chemistry , semicarbazone , amine gas treating , proton nmr , mannich reaction , carbon 13 nmr , solvent , microwave oven , nuclear chemistry , catalysis , materials science , physics , quantum mechanics , metallurgy
Microwave‐assisted synthesis has been found to increase both reaction rates and yields via more efficient heating compared with standard thermal conduction. Dry reaction of isatins with thiosemicarbazide and their thiosemicarbazone with secondary amine on acid—washed K10 in microwave oven afforded isatin‐3‐thiosemicarbazones and N‐Mannich bases in reasonably good yield. The chemical structures were confirmed by means of 1 H NMR, IR spectral data, and elemental analysis. J. Heterocyclic Chem., 46, 571 (2009).