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Synthesis and antitumor activity of novel pyrazolylenaminone and bis(pyrazolyl)ketones via hydrazonoyl halides
Author(s) -
Shawali Ahmad S.,
Sherif Sherif M.,
ElMerzabani Mahmoud M.,
Darwish Manal A. A.
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.113
Subject(s) - chemistry , halide , yield (engineering) , combinatorial chemistry , cancer cell lines , medicinal chemistry , organic chemistry , cancer cell , cancer , medicine , materials science , metallurgy
3‐Acetyl‐4‐benzoyl‐1,5‐diphenylpyrazole reacts with DMF‐DMA to give the novel enaminone 2 . The reaction of the latter with various hydrazonoyl halides afforded regioselectively the respective substituted (3‐pyrazolyl)(4‐pyrazolyl)ketones 4 in good over all yield. The preliminary screening for the antitumor activity of the synthesized compounds 2 and 4a , 4b , 4c , 4d , 4e , 4f , 4g against human breast cancer cell line (MCF‐7) revealed that both compounds 2 and 4b have high‐antitumor activity. SAR is discussed. J. Heterocyclic Chem., 46, 548 (2009).