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An efficient synthesis of indeno[1,2‐ b ]pyridine and benzo[ h ]quinoline derivatives under solvent‐free conditions
Author(s) -
Rong Liangce,
Han Hongxia,
Jiang Hong,
Tu Shujiang
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.112
Subject(s) - chemistry , quinoline , malononitrile , pyridine , solvent , aryl , sodium hydroxide , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl , catalysis
An efficient and convenient multicomponent reaction for the preparation of 4‐aryl‐2‐oxo‐2,5‐dihydro‐1 H ‐indeno[1,2‐ b ]pyridine‐3‐carbonitrile and 4‐aryl‐2‐oxo‐1,2,5,6‐tetrahydrobenzo[ h ]quinoline‐3‐carbonitrile derivatives by the 2,3‐dihydroinden‐1‐one or 3,4‐dihydronaphthalen‐1(2 H )‐one, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide under solvent‐free condition is reported. The short reaction time coupled with the simplicity of the reaction procedure makes this method one of the most efficient methods for the synthesis of these classes of compounds. J. Heterocyclic Chem., 46, 465 (2009).