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Zeolite‐Supported One‐Pot Synthesis of Bis‐azetidinones under Microwave Irradiation
Author(s) -
Jetti Venkateshwarlu,
Pagadala Ramakanth,
Meshram Jyotsna S.,
Chopde Himani N.,
Malladi Latha
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1108
Subject(s) - chemistry , bacillus subtilis , proteus vulgaris , antibacterial activity , klebsiella pneumoniae , escherichia coli , bacteria , elemental analysis , cycloaddition , staphylococcus aureus , microwave irradiation , proton nmr , carbon 13 nmr , zeolite , nuclear chemistry , catalysis , organic chemistry , biochemistry , genetics , biology , gene
In an attempt to synthesize antibacterial agents effective against gram‐positive and gram‐negative bacteria, the efficient synthesis of novel bis‐azetidinones ( 3a–j ) has been established. Thus, cycloaddition reaction of substituted bis‐imines with chloroacetylchloride under microwave irradiation in the presence of zeolite yielded bis‐azetidinones ( 3a–j ). Structures of the synthesized compounds have been elucidated on the basis of their elemental analysis and spectral data (IR, 1 H‐NMR, 13 C‐NMR, and mass spectra). The synthesized bis‐azetidinones were screened for their antibacterial activity against five microorganisms: Bacillus subtilis , Proteus vulgaris , Staphylococcus aureus , Klebsiella pneumoniae , and Escherichia coli . They were found to exhibit good to moderate antibacterial activity .